Chemistry of cefoperazone - cefoperazone is a third generation cephalosporin, cefoperazone sodium with piperazine side chain, there antipseudomonal activity. It comes as a white crystalline powder and is readily soluble in water and sparingly soluble in alcohol. At room temperature, temperature, cefoperazone sodium, which has a maximum solubility in compatible IV solution 475 mg / ml (at a concentration of 333 mg / ml, intense and prolonged shaking may) be required. Cefoperazone dissolved have a pH of 4.5 to 6.5. Each gram contains 1.5 mmol sodium.
Storage / Stability / Compatibility of Cefoperazone
Sterile Powder for Injection should be stored at a temperature below 25 ° C and protected from light. After the resolution is not well protected from light. After the dissolution of cefoperazone sodium is generally stable at room temperature for 24 hours up to 5 days if refrigerated at different IV solutions (eg sterile or bacteriostatic water for injection, dextrose in water / salt / LRS solution Ringer's lactate injections, and IV saline Normasol R). Cefoperazone when frozen to -2 to -10 ° C in dextrose, salt, or sterile water for injection, is Cefoperazone sodium for 3 weeks (dextrose solution) for 5 weeks stable (water or saline solution).
Cefoperazone sodium is reported to be in line with cimetidine HCl, clindamycin phosphate, furosemide, and heparin sodium, acyclovir sodium, cyclophosphamide, esmolol HCl, famotidine, hydromorphone HCl, magnesium sulfate and morphine sulfate. This is allegedly in violation of some TPN mixture, doxapram HCl, gentamicin sulfate, Hetastarch, labetolol HCl, meperidine HCl, odansetron HCl, perphenazine, promethazine and sargostim.
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